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I have to be one of the last people Prime Minister Justin Trudeau would accept year-end advice from, ahead of only his almost-certain successor, Pierre Poilievre. And I’m not really interested in helping the Liberals recover from their death spiral. But in the spirit of “country over party,” here goes.

Biomedical startups are using artificial intelligence to predict the response patients will have to cancer treatments, aiming to increase the success of drugs in clinical trials and tailor therapies to individuals. As data accumulate from clinical trials and fields such as gene and protein research, AI is helping scientists sift through large volumes of information to uncover signatures that correlate with response—or resistance—to treatment. Startups are using it to predict which drugs are likely to work in clinical studies and create tests to help doctors choose treatments.

Also Read: Budget 2024: 10 experts share what they expect from the coming Budget According to Deloitte India, the upside risks in the current environment include strong economic growth, robust spending on infrastructure and recovery in the MSME sector. On the contrary, the downside risks include a rise in inflation, election uncertainties, geopolitical concerns and diverging demand gaps. “India will have to rely on its own domestic demand to drive its growth, specifically, private consumption and investment spending.

OSIRIS-REx is now "already well on its way with a new name to explore a new destination (Apophis)", the NASA said. In a statement on December 22, the US space agency said, "The former OSIRIS-REx spacecraft sets off on a (seven-year, 4 billion-mile journey) journey to study asteroid Apophis and take advantage of the asteroid’s 2029 flyby of Earth, the likes of which hasn’t happened since the dawn of recorded history." When Apophis was discovered in 2004, the asteroid was gained notoriety as one of the most hazardous asteroids that could impact Earth.

Russia launched 122 missiles and 36 drones against Ukrainian targets, officials said Friday, killing at least 13 civilians in what an air force official said was the biggest aerial barrage of the 22-month war. The Ukrainian air force intercepted 87 of the missiles and 27 of the Shahed-type drones overnight, Ukraine's military chief Valerii Zaluzhnyi said. Air Force commander Mykola Oleshchuk wrote on his official Telegram channel: «The most massive aerial attack» since Russia's full-scale invasion in February 2022.

Gaurav Bissa, VP, InCred Equities, says, “going forward, largecaps, especially larger banks like Kotak Bank and HDFC Bank will drive the markets going forward. So, the view remains positive. It is a buy-on-declines market. But the kind of move that we have seen from lower levels of 15,000 to higher levels of almost 22,000 that might not get repeated. But the overall sentiment will remain positive.” With 2023 coming to an end and markets gaining close to around 20% in this calendar year, what is your target for 2024 for Nifty? Gaurav Bissa: Our targets for mid-2024 were 21,000-21,500, those have been surpassed ferociously in 2023 itself. And now, I do not see we can have a similar kind of upside where in six months we can have 2,000-3,000 points coming in, even more than that. But yes, more towards 22,500 cannot be ruled out on the higher end. 20,000 is where Nifty can head towards. And largecaps will now take a front seat at least for next few months, where we have seen a very robust upside in midcaps and smallcaps.

Gold price may touch ₹67,000 in 2024 on the rise in demand. Should you buy? Mint collected the views of several experts regarding their opinions on gold's prospects in 2024. Here's what they said: Gold is a good investment option currently given the expectation of a prolonged two to three years rate cut cycle and consequent dollar weakness.

1. Financial literacy: Anshul Arzare, MD and CEO, Yes Securities, believes that staying updated, mitigating risks, being persistent, planning, and budgeting, are essential ingredients for financial success. 2. Caution against unforeseen occurrences: Arzare also advised that it's prudent to anticipate unforeseen occurrences, such as the existing geopolitical tensions and the recovery challenges faced by developing nations post Covid.

Tata Motors share price has doubled in 2023, making it the only stock in the Nifty 50 index to achieve this feat this year. Tata Motors share price opened at ₹755 against the previous close of ₹753.90 and jumped 6.5 per cent to hit its fresh 52-week high of ₹802.90 on the NSE in an otherwise weak market. With this, the stock's year-to-date gain surged to 107 per cent.

Satish Kumar, the president of Lakshmi Narayan Mandir in Surrey, Canada, was reportedly targeted in a shooting. Recent TV reports revealed that at least 14 gunshots hit Kumar's home on Thursday night.

Endurance Technologies Ltd. with a target price of Rs 2000.

By Sudarshan Varadhan

By Khanh Vu

Day trading guide for today: On account of strong sentiments in Asian stock market, Dalal Street ended higher for fifth straight session on Thursday. Nifty 50 index ended at 21,778 levels after climbing to a new peak of 21,801. BSE Sensex finished at 72,410 levels after hitting record high of 72,484.

PTI, Karnataka CM stated on Thursday that the state government is planning to introduce an ordinance to enforce this requirement. However, he issued a cautionary statement following the recent vandalism of business establishments by pro-Kannada activists. “Anyone can protest but no one should cause damage to government or public property," he asserted.

Buy or sell stocks for today: Following strong sentiments in Asian stock market, Dalal Street ended higher for fifth straight session on Thursday. Nifty 50 index ended at 21,778 levels after climbing to a new peak of 21,801. BSE Sensex finished at 72,410 levels after hitting record high of 72,484.

Ecommerce giants Amazon and Flipkart's cumulative ad revenue rose 39% to Rs 8,705 crore in the fiscal year through March 2023, as advertisers across categories used the platforms amid growth in their user base, as per data filed by the companies with the Registrar of Companies (RoC). In FY23, Amazon Seller Services, the marketplace arm of Amazon, recorded 29% growth in ad revenue at Rs 5,380 crore, according to the RoC filings sourced from business intelligence platform Tofler. For Flipkart Internet, the marketplace arm of Flipkart, revenue from this segment rose 60% to Rs 3,325 crore.

diesel buses, more than a third of the total on roads, with electric ones over the next seven years. Apart from lowering vehicular emissions, this is also expected to catalyse investments in the electric vehicle (EV) ecosystem in the country. The replacement plan includes 200,000 electric buses for state transport undertakings (STUs), 550,000 for private operators, and 50,000 for schools and employee transportation by 2030, top government sources told ET. Designed to electrify the country's public transport systems, the plan is likely to replace the third leg of the Faster Adoption and Manufacturing Electric Vehicles (FAME) incentive programme and pitch India as a global manufacturing hub for EVs. To put the plan in context, about 138,000 electric buses were sold in China and 4,000 in Europe in 2022. «Replacing diesel buses with electric ones will not only address environmental concerns but also help create an ecosystem for electric vehicles,» said one of the persons cited above.

Hero MotoCorp rose 2.9% to an all-time closing high of ₹4,174 in Thursday's trading, as the recent bullish wave has resulted in a technical breakout in stock, opening the likelihood of further gains of as much as 56% from current levels. Analysts are recommending investors to buy the stock on dips as business prospects too are favouring the company at this juncture. Hero shares crossed the ₹4,000 level on December 26 for the first time after September 2017 amid the run-up in recent weeks.

NEW DELHI : The government is considering a 50% duty on the export of molasses. The idea is to ensure enough supplies to meet the target for cleaner and more efficient ethanol-blended petrol, two officials aware of the matter said on the condition of anonymity. India is the world’s largest molasses exporter, contributing about 25% to global trade.

manufacturing and increasing exports to USD 500 billion by 2030 from 10-11 sectors, including automobiles, pharma, textiles, medical devices and chemicals, a senior official said on Thursday. These issues were discussed during a meeting called by the Commerce and Industry Ministry on Thursday. The meeting was convened by the Department of Promotion of Industry and Internal Trade (DPIIT) in collaboration with Invest India and SCALE (Steering Committee for Advancing Local Value-Add and Exports) Committee to unveil outcomes and recommendations made during the Chintan Shivir for Manufacturing, held on October 12 at Bharat Mandapam here.