New Covid-19 variant EG.5 on the rise in US, other countries

economictimes.indiatimes.com:

EG.5 is on the rise in the US. The variant is causing about 17 per cent of the new Covid-19 cases in the country compared to 16 per cent for the next most common lineage, XBB.1.16, according to the latest estimates from the US Centers for Disease Control and Prevention, CNN reported. The new variant is a spinoff of the XBB recombinant strain of the Omicron family.

EG.5, compared to its parent XBB.1.9.2, has one extra mutation to its spike, at position 465. This mutation has appeared in other coronavirus variants before. Scientists are still not aware what the new mutation enables the virus to do.

The 465 mutation is present in about 35 per cent of coronavirus sequences reported worldwide, including another that's rising in prevalence in the Northeast, FL.1.5.1, suggesting that it is conveying some kind of evolutionary advantage over previous versions, as per CNN. EG.5 now has its own offshoot, EG.5.1, that adds a second mutation to the spike. That one is also spreading rapidly.

A professor of microbiology and immunology, Dr David Ho has been testing these variants in his lab at Columbia University to see how resistant they have become to the antibodies we have to defend against them. Ho said in an email to CNN: «Both are only slightly more resistant to neutralizing antibodies in the serum of infected and vaccinated persons.» Clinically, he said, these variants don't seem to be causing different or more severe symptoms than the viruses that came before them. «It basically has some more immune escape compared to the ones that were precedents in this XBB series,» said Dr Eric Topol, a cardiologist at the Scripps Translational Research Institute.