Domestic benchmark index NSE Nifty ended 82.0 points down at 19443.55, while the BSE Sensex closed 325.58 points down at 64933.87.
On the other hand, Crest Ventures, Everest Kanto, SMC Global Secur, Wockhardt and Thejo Engg stocks hit their fresh 52-week highs today.
In the Nifty 50 index, Coal India Ltd, Eicher Motors, Hindalco, M&M and BPCL were among the top gainers on the NSE in the today's trade.
Meanwhile, SBI Life, Bajaj Finance, Infosys, Apollo Hospital and Tech Mahindra were among the top losers of the day.