Local Russian officials have reported that a fuel depot in a southern border region exploded on Wednesday morning.
The blast allegedly occurred in Orel province, around 200 kilometres from the Ukrainian frontier. No casualties have been reported.
The suspected drone attack comes after dozens of missile strikes at several cities in Ukraine on Tuesday.
Since the start of the war, several fuel and ammunition depots in southern Russia have been targeted by drones or helicopters. In October, the regional capital of Belgorod suffered power outages after an oil depot and power plant were shelled.
Orel province would be the furthest region from the Ukrainian border to be hit. Russian authorities have blamed the Ukrainian military for the strike.
On Tuesday, two people were killed and three others wounded in other Ukrainian strikes on Belgorod, according to governor Vyacheslav Gladkov.
Meanwhile, Russian forces say they have withdrawn workers from the Ukrainian town of Nova Kakhovka, on the east bank of the Dnipro River.
Moscow claims that Ukraine's military is shelling near the town's strategic hydroelectric dam, which supplies water to the Kherson region. Kyiv has rejected the claims and says Moscow has "undermined" the dam.
Kherson was one of four regions of southeastern Ukraine that Russia annexed in September after holding so-called "referendums".
But Russian forces left the city of Kherson last week after eight months of occupation, amid a Ukrainian counteroffensive.
Ukrainian officials say they have fully restored power in seven regions, including the capital Kyiv after Russia fired a barrage of missiles at Ukraine on Tuesday.
Work to restore electricity was also underway in seven other regions, according to Kyrylo Tymoshenko, deputy
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