Celine Dion's Diagnosis unraveled: What is Stiff Person Syndrome — triggers, symptoms & treatment

economictimes.indiatimes.com:

stiff person syndrome (SPS), fans and the public have been left curious about this rare neurological disorder. The Canadian singer was compelled to cancel her world tour, including many UK dates, due to the condition. Her sister shed some light on the decision, emphasizing the importance of rest and listening to one's body.

Stiff person syndrome is a rare neurological disorder characterized by progressive muscle stiffness and recurring painful episodes of muscle spasms. The severity of rigidity fluctuates, with symptoms sometimes improving and then worsening unpredictably. Various stimuli, such as sudden noise, light physical contact, or exposure to cold, can trigger spasms. If left untreated, the condition can escalate and hinder a person's ability to perform daily tasks like walking.

According to MedicineNet, individuals diagnosed with stiff person syndrome can live between 6 to 28 years from the onset of symptoms before succumbing to the condition. While there is currently no cure for SPS, several treatments aim to manage symptoms or slow down the progression of the disorder. Patients have options such as immunotherapy or disease-modifying treatments to alleviate their condition.

Despite ongoing research, stiff person syndrome's exact causes remain elusive. However, it is believed to be associated with an autoimmune reaction. The immune system may erroneously target a protein called glutamic acid decarboxylase, which plays a role in producing gamma-aminobutyric acid.

Stiff-person syndrome presents with symptoms such as stiff muscles in the trunk, arms, and