Scientists at the Medical Research Council Laboratory of Medical Science and Imperial College London found a way to increase the lifespan of laboratory mice by 25 years and have hopes that it could be applied to humans.
The researchers discovered that deactivating a protein called interleukin-11 or IL-11 significantly extended the healthy lifespan of the mice. This treatment greatly reduced cancer-related deaths and decreased the prevalence of diseases associated with chronic inflammation and poor metabolism, both of which are common in aging.
Mice that received this therapy lived an average of 155 weeks, compared to 120 weeks for untreated mice. These treated mice were nicknamed "supermodel grannies" in the lab due to their youthful appearance.
In humans, levels of this protein rise as they age and have been linked to various age-related conditions, such as chronic inflammation, metabolic disorders, muscle wasting, and frailty, according to past research.
Professor Stuart Cook, who was a co-corresponding author, from the Medical Research Council Laboratory of Medical Science (MRC LMS), Imperial College London, and Duke-NUS Medical School in Singapore, told Independent Co UK, that the mice who underwent this treatment, saw fewer signs of aging, those who were diagnosed with cancer, got noticeably better and also experienced an improvement in muscle strength.
He also added: “Previously proposed life-extending drugs and treatments have either had poor side-effect profiles, or don’t work in both sexes, or could