People taking Wegovy and Ozempic have lower risk of suicidal thoughts vs. older drugs, study finds
A new federal study finds that people taking popular diabetes and obesity drugs Ozempic and Wegovy had a lower risk of suicidal thoughts than those taking other medications to treat the same conditions
People taking the popular diabetes and obesity drugs Ozempic and Wegovy had a lower risk of suicidal thoughts than those taking other medications to treat the same conditions, a new federal study finds.
The research, funded by the National Institutes of Health, was published Friday and comes as European and U.S. regulators look into anecdotal reports that people taking the drug, semaglutide, had thoughts of self-harm.
NIH and Case Western Reserve University researchers analyzed electronic medical records from more than 1.8 million patients prescribed semaglutide or another drug to treat obesity or diabetes between 2017 and 2022. They included about 240,000 patients treated for obesity or being overweight and nearly 1.6 million patients treated for diabetes.
They found that people taking semaglutide had a 49% to 73% lower risk of first-time or recurring suicidal thoughts than those taking another drug for those conditions during a six-month follow-up period.
The researchers called for closer evaluation of reports of suicidal thoughts linked to the drugs and for patients to be followed for a longer period of time. Their review only considered patients taking semaglutide or another drug for diabetes or obesity, not those taking semaglutide in the general population.
Study co-author Dr. Rong Xu, of Case Western, also noted obesity and diabetes are risk factors on their own for suicidal thoughts. But the study wasn’t designed to determine if the GLP-1 drugs reduced those thoughts.
The scientists launched the review after
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