Pfizer drug extends life for people with rare form of lung cancer
Pfizer lung cancer drug has been shown to greatly reduce tumor progression and improve survival outcomes for people in the advanced stages of a rare form of the disease, according to trial results published Friday.
Lorlatinib, which is already approved and available under the brand name Lorbrena in the United States, was tested in a clinical trial of hundreds of people with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).
Roughly half received lorlatinib while the rest received crizotinib, an earlier generation drug.
After five years of follow-up, more than half of patients treated with lorlatinib did not see their cancer progress.
«We're talking about patients with advanced metastatic disease — so this is actually a truly unprecedented finding,» Pfizer's thoracic oncology strategy lead Despina Thomaidou told AFP.
Sixty percent of patients receiving lorlatinib, an oral one a day tablet, were alive without disease progression after five years compared to 8 percent on crizotinib.
«There is an 81 percent reduction in the risk of progression or death,» added Thomaidou.
Lung cancer is the leading cause of cancer deaths globally.
NSCLC accounts for more than 80 percent of lung cancers, with ALK-positive tumors responsible for roughly five percent of NSCLC cases, translating to around 72,000 new cases each year worldwide.
ALK-positive NSCLC mostly affects younger patients and is not strongly linked to smoking. It is also very aggressive — 25-40 percent of people with
