Patient with rare medical condition recovers with life-saving bone marrow transplant in Delhi
A team of doctors in Delhi has recently treated a 41-year-old patient with high-risk myelodysplastic syndrome (MDS) with a life-saving bone marrow transplant. MDS are a group of disorders caused when something disrupts the production of blood cells. In certain cases, MDS may progress to leukemia.
According to the doctors, there was a high chance of progression to frank blood cancer i.e. acute myeloid leukemia in this patient. The team of doctors led by Dr. Divya Bansal, Consultant – Clinical Hematology and BMT at HCMCT Manipal Hospitals, Dwarka, performed a bone marrow transplant.
“This was a challenging case as the patient had no siblings who were a perfect match (100%) for the bone marrow transplant. Additionally, no suitable, fully matched donor was available. However, the donor for the bone marrow transplant was the patient’s half-matched brother. Despite repeated stem cell harvests, ideal dose of 7-8 million stem cells was not able to be procured from the donor, a total of 4 million stem cells were collected throughout the process, posing a danger of primary graft failure,” the hospital said in a statement.
The doctors explained that in this case, the patient’s MDS was associated with a high-risk cytogenetics defect known as monosomy 7, which indicates the loss of one copy of chromosome 7. The patient first responded well to azacytidine therapy, a widely used medicine that causes remission and supports healthy blood cell development, they revealed.
“The patient’s journey was filled with ups and downs, but we are thrilled to witness a positive outcome despite the challenges. Several challenges arose during the transplant process, including a serious bacterial infection that resulted in stomach mucosa shedding,
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