Domestic benchmark index NSE Nifty fell 68.35 points to 21710.35, while the BSE Sensex traded 230.73 points down at 72179.65.
On the other hand, Surya Roshni, Vineet Laboratories, Trans & Rectif, Wendt India and HMA Agro Industries stocks hit their fresh 52-week highs today.
In the Nifty 50 index, Tata Consumer, Tata Motors, Adani Ports SEZ, HUL and Wipro were among the top gainers on the NSE.
BPCL, NTPC, ONGC, Coal India Ltd and SBI were among the top losers.